Publications

Tanycytic degeneration impairs tau clearance and contributes to Alzheimer’s disease pathology. Cell Press Blue. doi: 10.1016/j.cpblue.2026.100003. Sauvé F, Martinez-Gomez R, Mbouamboua Y, Ternier G, Nampoothiri S, Dupré E, Garcia L, Couralet M, Dewisme J, Lebouvier T, Danis C, Rasika S, Dhenain M, Kim Y-B, Ciofi P, Buée L, Landrieu I, Pasquier F, Lilamand M, Paquet C, Giacobini P, Barbry P, Maurage C-A, Nogueiras R, Schwaninger M, Prevot V (2026).

Compartmentalized VEGF receptor expression in hypothalamic tanycytes reveals a novel non-endothelial axis of VEGF signaling : Tanycytes as a novel non-endothelial target of VEGF signaling. Fluids Barriers CNS. Doi: 10.1186/s12987-026-00774-w. PMID: 41691203. Desruelle O, Leclerc M, Nampoothiri S, Fernandois D, Maurage CA, Schwaninger M, Prevot V, Martinez-Corral I (2026).

Preoptic kisspeptin-nNOS-GnRH (KiNG) neuronal network regulates LH rhythmicity through activation-inhibition in mice. Nat Commun. Doi: 10.1038/s41467-026-69316-0. Online ahead of print. PMID: 41667486 Delli V, Moulinier M, Lazaridou AM, Seux CA, Nair S, Lhomme T, Dehame J, Fernandois D, Rasika S, Lemoine D, Carleton A, Chachlaki K (2026)

Isolation and Culture of White and Brown Preadipocytes from Mouse Embryos. J. Vis. Exp. JoVE. https://doi.org/10.3791/70101 Canatelli-Mallat, M., Amaouche, M., Bongiovanni, S., Mayeuf-Louchart, A., 2026.

A single-cell and spatial atlas of early human olfactory development. P. Nat Commun. 2026 Apr 17;17(1):3537. doi: 10.1038/s41467-026-71595-6 Mbouamboua Y, Lebrigand K, Nampoothiri S, Couralet M, Arguel MJ, Cotellessa L, Allet C, Prevot V, Barbry P, Giacobini

Preventing and Correcting Polycystic Ovary Syndrome by Targeting Anti-Müllerian Hormone Signaling in Minipuberty and Adulthood in Mice. Cell Metabolism. doi: 10.1016/j.cmet.2025.03.013. Cotellessa L, Sobrino V, Silva MSB, Delit M, Maitre H, Caron E, Ternier G, Lima NdS, Lhomme T, Giton F, Sorrentino A, Carraresi L, Di Nardo G, Nogueiras R, Tena-Sempere M, Prevot V, Giacobini P (2025).

Oxytocin neurons drive melanocortin circuit maturation via vesicle release during a neonatal critical period. PLoS Biol. 12;23(11):e3003158. doi: 10.1371/journal.pbio.3003158. ECollection 2025 Nov. PMID: 41223213 Barelle PY, Schaller F, Park S, Caron E, Klucznik J, Ciofi P, Muscatelli F, Bouret SG (2025).

Investigation of a mouse model of Prader-Willi syndrome with combined disruption of Necdin and Magel2. JCI Insight. 6:e185159. PMID: 40048253 Barelle PY, Sicardi A, Schaller F, Buron J, Becquet D, Omnes F, Watrin F, Alifrangis MS, Santos C, Menuet C, François-Bellan AM, Caron E, Klucznik J, Prevot V, Bouret SG, Muscatelli F. (2025)

A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice.
Decoster L, Trova S, Zucca S, Bulk J, Gouveia A, Ternier G, Lhomme T, Legrand A, Gallet S, Boehm U, Wyatt A, Wahl V, Wartenberg P, Hrabovszky E, Rácz G, Luzzati F, Nato G, Fogli M, Peretto P, Schriever SC, Bernecker M, Pfluger PT, Steculorum SM, Bovetti S, Rasika S, Prevot V, Silva MSB, Giacobini P. Nat Neurosci. 2024 Sep;27(9):1758-1773. doi: 10.1038/s41593-024-01724-1. Epub 2024 Aug 2. PMID: 39095587

A plastic aggrecan barrier modulated by peripheral energy state gates metabolic signal access to arcuate neurons.
Kuczynski-Noyau L, Karmann S, Alberton P, Martinez-Corral I, Nampoothiri S, Sauvé F, Lhomme T, Quarta C, Apte SS, Bouret S, Aszodi A, Rasika S, Ciofi P, Dam J, Prévot V, Mattot V. Nat Commun. 2024 Aug 7;15(1):6701. doi: 10.1038/s41467-024-50798-9. PMID: 39112471

Estrogen receptor-α signaling in tanycytes lies at the crossroads of fertility and metabolism.
Fernandois D, Rusidzé M, Mueller-Fielitz H, Sauve F, Deligia E, Silva MSB, Evrard F, Franco-García A, Mazur D, Martinez-Corral I, Jouy N, Rasika S, Maurage CA, Giacobini P, Nogueiras R, Dehouck B, Schwaninger M, Lenfant F, Prevot V. Metabolism. 2024 Sep;158:155976. doi: 10.1016/j.metabol.2024.155976. Epub 2024 Jul 15. PMID: 39019342

Tanycytic transcytosis inhibition disrupts energy balance, glucose homeostasis and cognitive function in male mice.
Duquenne M, Deligia E, Folgueira C, Bourouh C, Caron E, Pfrieger F, Schwaninger M, Nogueiras R, Annicotte JS, Imbernon M, Prévot V. Mol Metab. 2024 Sep;87:101996. doi: 10.1016/j.molmet.2024.101996. Epub 2024 Jul 22. PMID: 39047908

Inhibition of WNT/β-catenin signalling during sex-specific gonadal differentiation is essential for normal human fetal testis development. Cell Commun Signal. doi: 10.1186/s12964-024-01704-9. Lundgaard Riis M, Delpouve G, Nielsen JE, Melau C, Langhoff Thuesen L, Juul Hare K, Dreisler E, Aaboe K, Tutein Brenøe P, Albrethsen J, Frederiksen H, Juul A, Giacobini P and Jørgensen A (2024).

Hypothalamic neuroglial plasticity is regulated by anti-Müllerian hormone and disrupted in polycystic ovary syndrome.
Barbotin AL, Mimouni NEH, Kuchcinski G, Lopes R, Viard R, Rasika S, Mazur D, Silva MSB, Simon V, Boursier A, Pruvo JP, Yu Q, Candlish M, Boehm U, Bello FD, Medana C, Pigny P, Dewailly D, Prevot V, Catteau-Jonard S, Giacobini P.
EBioMedicine. 2023;90:104535. doi: 10.1016/j.ebiom.2023.104535PMID: 37001236 

Overactivation of GnRH neurons is sufficient to trigger polycystic ovary syndrome-like traits in female mice.
Silva MSB, Decoster L, Delpouve G, Lhomme T, Ternier G, Prevot V, Giacobini P.
EBioMedicine. 2023;97:104850. doi: 10.1016/j.ebiom.2023.104850.PMID: 37898094  

Maternal low-calorie sweetener consumption rewires hypothalamic melanocortin circuits via a gut microbial co-metabolite pathway.
Park S, Belfoul AM, Rastelli M, Jang A, Monnoye M, Bae H, Kamitakahara A, Giavalisco P, Sun S, Barelle PY, Plows J, Jang C, Fodor A, Goran MI, Bouret SG.
JCI Insight. 2023;8(10):e156397. doi: 10.1172/jci.insight.156397.PMID: 37014702

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death.
Sauve F, Nampoothiri S, Clarke SA, Fernandois D, Ferreira Coêlho CF, Dewisme J, Mills EG, Ternier G, Cotellessa L, Iglesias-Garcia C, Mueller-Fielitz H, Lebouvier T, Perbet R, Florent V, Baroncini M, Sharif A, Ereño-Orbea J, Mercado-Gómez M, Palazon A, Mattot V, Pasquier F, Catteau-Jonard S, Martinez-Chantar M, Hrabovszky E, Jourdain M, Deplanque D, Morelli A, Guarnieri G, Storme L, Robil C, Trottein F, Nogueiras R, Schwaninger M, Pigny P, Poissy J, Chachlaki K, Maurage CA, Giacobini P, Dhillo W, Rasika S, Prevot V.
EBioMedicine. 2023;96:104784. doi: 10.1016/j.ebiom.2023.104784. PMID: 37713808 

Protocol for simultaneous patch-clamp recording from tanycytes and neurons in living mouse brain slices.
Lhomme T, Prévot V.
STAR Protoc. 2023 20;4(4):102571. doi: 10.1016/j.xpro.2023.102571. PMID: 37733593 

COVID-19 could worsen cerebral amyloid angiopathy.
Dewisme J, Lebouvier T, Vannod-Michel Q; Lille COVID Research Network (LICORNE); Prevot V, Maurage CA.
J Neuropathol Exp Neurol. 2023 21;82(9):814-817. doi: 10.1093/jnen/nlad049.PMID: 37428895 

Cell proliferation and glial cell marker expression in the wall of the third ventricle in the tuberal region of the male mouse hypothalamus during postnatal development.
Coutteau-Robles A, Prevot V, Sharif A.
J Neuroendocrinol. 2023;35(3):e13239. doi: 10.1111/jne.13239. PMID: 36863859

Male minipuberty involves the gonad-independent activation of preoptic nNOS neurons.
Delli V, Dehame J, Franssen D, Rasika S, Parent AS, Prevot V, Chachlaki K.
Free Radic Biol Med. 2023 Jan;194:199-208. doi: 10.1016/j.freeradbiomed.2022.11.040. PMID: 36470319

Changes in circulating forms of anti-Müllerian hormone and androgens in women with and without PCOS: a systematic longitudinal study throughout pregnancy. Human Reproduction doi: 10.1093/humrep/dead050. Peigné M, Simon S, Pigny P, Mimouni N.E.H., Martin C, Dewailly D, Catteau-Jonard S, Giacobini P (2023).

Defective Jagged1 signaling impacts GnRH development and contributes to congenital hypogonadotropic hypogonadism. JCI Insight doi: 10.1172/jci.insight.161998. Cotellessa L, Marelli F, Duminuco P, Adamo M, Papadakis GE, Bartoloni L, Sato N, Lang-Muritano M, Troendle A, Dhillo WS, Morelli A, Guarnieri G, Pitteloud N, Persani L, Bonomi M, Giacobini P, Vezzoli V (2023).

MuscleJ2: a rebuilding of MuscleJ with new features for high-content analysis of skeletal muscle immunofluorescence slides. Skeletal Muscle 13, 14. Danckaert A.*, Trignol A., Le Loher G., Loubens S., Staels B., Duez H., Shorte, S.L., Mayeuf-Louchart A.* (2023).

Female sexual behavior is disrupted in a preclinical mouse model of PCOS via an attenuated hypothalamic nitric oxide pathway. PNAS. doi:10.1073/pnas.2203503119. Silva MSB, Decoster L, Trova S, Mimouni NEH, Delli V, Chachlaki K, Yu Q, Boehm U, Prevot V, Giacobini P (2022)

Deciphering the transcriptional landscape of human pluripotent stem cell-derived GnRH neurons: the role of Wnt signaling in patterning the neural fate. Stem Cells doi: 10.1093/stmcls/sxac069. Wang Y, Madhusudan S, Cotellessa L, Kvist J, Eskici N, Yellapragada N, Pulli K, Lund C, Vaaralahti K, Tuuri T, Giacobini P, Raivio T (2022).

Precocious puberty in narcolepsy type 1: Orexin loss and/or neuroinflammation, which is to blame? Sleep Med Rev. 101683. PMID: 36096986 Melzi S, Prevot V, Peyron C (2022)

[GnRH neurons sculpt their neuroglial environment in infancy to enable proper sexual maturation and fertility]. Med Sci (Paris). 2022 May;38(5):428-430. doi: 10.1051/medsci/2022047. Sharif A, Prévot V.

Development of the gonadotropin-releasing hormone system. Journal of Neuroendocrinology doi: 10.1111/jne.13087. Duittoz A.H., Forni P.E., Giacobini P., Golan M., Mollard P., Negrón A.L., Radovick S., Wray S. (2022).

Loss-of-Function Mutations in SEMA3F and PLXNA3 Encoding Semaphorin-3F and its Receptor Plexin-A3 Respectively Cause Idiopathic Hypogonadotropic Hypogonadism. Genetics in Medicine doi: 10.1038/s41436-020-01087-5. Kotan LD, Ternier G, Cakir AD, Emeksiz HC, Turan I, Delpouve G, Kardelen AD, Ozcabi B, Isik E, Mengen E, Cakir EDP, Yuksel A, Agladioglu SY, Dilek SO, Evliyaoglu O, Darendeliler F, Gurbuz F, Akkus G, Yuksel B, Giacobini P , Topaloglu AK (2021).

GnRH Neurons: The Return of the Rat. Endocrinology 162:bqaa207. Commentary PMID: 33159199 Martinez-Corral I, Prevot V (2021)

Unveiling the Importance of Tanycytes in the Control of the Dialogue Between the Brain and the Periphery. Nampoothiri S, Duquenne M, Prevot V.

In: Tasker JG, et al., ed. Glial-Neuronal Signaling in Neuroendocrine Systems. Masterclass in Neuroendocrinology Series. Switzerland: Springer Nature:255-284, 2021.

Neurogenesis in the adult hypothalamus: A distinct form of structural plasticity involved in metabolic and circadian regulation, with potential relevance for human pathophysiology. Handb Clin Neurol. 2021;179:125-140. Sharif A, Fitzsimons CP, Lucassen P.

The proportion of cleaved anti-Müllerian hormone is higher in serum but not follicular fluid of obese women independently of polycystic ovary syndrome. Peigné M., Pigny1 P., Pankhurst M.W., Drumez E., Loyens A., Dewailly D., Catteau-Jonard S., Giacobini P. Reproductive BioMedicine Online 2020 , 41:1112-1121. DOI: 10.1016/j.rbmo.2020.07.020.

Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism. Messina A, Pulli K, Santini S, Acierno J, Känsäkoski J, Cassatella D, Xu C, Casoni F, Malone SA, Ternier G, Conte D, Sidis Y, Tommiska J, Vaaralahti K, Dwyer A, Gothilf Y, Merlo GR, Santoni F, Niederländer NJ, Giacobini P*, Raivio T*, Pitteloud N* Am J Hum Genet. 2020, 106:58-70. DOI:10.1016/j.ajhg.2019.12.003. * Equal contribution.

Neuropilin-1 expression in GnRH neurons regulates prepubertal weight gain and sexual attraction. Vanacker C, Trova S, Shruti S, Casoni F, Messina A, Croizier S, Malone S, Ternier G, Hanchate NK, Bouret SG, Ciofi P, Giacobini P, Prevot V Embo J 2020. 39, e104633

The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates. Park S, Aintablian A, Coupe B, Bouret SG Nat Commun 2020. 11, 1914

Maternal obesity-induced endoplasmic reticulum stress causes metabolic alterations and abnormal hypothalamic development in the offspring. Park S, Jang A, Bouret SG PLoS Biol 2020. 18, e3000296

Hypothalamic Structural and Functional Imbalances in Anorexia Nervosa. Florent V, Baroncini M, Jissendi-Tchofo P, Lopes R, Vanhoutte M, Rasika S, Pruvo JP, Vignau J, Verdun S, Johansen JE, Pigeyre M, Bouret SG, Nilsson IAK, Prevot V. Neuroendocrinology. 2020. 110, 552-562.

New insights into anti-Müllerian hormone role in the hypothalamic-pituitary-gonadal axis and neuroendocrine development. Cell Mol Life Sci. doi: 10.1007/s00018-020-03576-x. Silva MSB, Giacobini P (2020)

HPG-dependent peri-pubertal regulation of adult neurogenesis in mice. Frontiers in Neuroanatomy doi: 10.3389/fnana.2020.584493. Trova S, Bovetti S, Pellegrino G, Bonzano S, Giacobini P, Peretto P.M (2020).

Characterization of the human GnRH neuron developmental transcriptome using a GNRH1-TdTomato reporter line in human pluripotent stem cells. Disease Models & Mechanisms doi: 10.1242/dmm.040105. Lund C, Yellapragada V, Vuoristo S, Balboa D, Trova S, Allet C, Eskici N, Pulli K, Giacobini P, Tuuri T, Raivio T (2020)

Reproductive Function During Chronodisruption: Model of Shiftwork in Rodents. Endocrinology 161: bqaa151. Commentary PMID: 32853386 Leysen V, Prevot V (2020)

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. Van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O’Rahilly S, Simerly RB, Consortium UK, , Minchin, J.E.N., Barroso, I., Jones, E.Y., Bouret, S.G. & Farooqi, I.S. Cell 2019. 176: 729-742 e18

Non-nutritive Sweeteners Induce Hypothalamic ER Stress Causing Abnormal Axon Outgrowth. Park, S., Sethi, S. & Bouret, S.G. Front Endocrinol (Lausanne) 2019. 10, 876.

Defective AMH signaling disrupts GnRH neuron development and function and contributes  to hypogonadotropic hypogonadism. Malone SA, Papadakis GE, Messina A, Mimouni NEH, Trova S, Imbernon M, Allet C, Cimino I,  Acierno J, Cassatella D, Xu C, Quinton R, Szinnai G, Pigny P, Alonso-Cotchico L, Masgrau L,  Maréchal JD, Prevot V, Pitteloud N, Giacobini P. Elife. 2019. 8:e47198. doi: 10.7554/eLife.47198

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.  van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton   MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova   EG, Mistry V, O’Rahilly S, Simerly RB; INTERVAL; UK10K Consortium, Minchin JEN, Barroso I, Jones   EY, Bouret SG, Farooqi IS.  Cell. 2019.  176:729-742.e18. doi: 10.1016/j.cell.2018.12.009  

Circulating anti müllerian hormone and steroid hormone levels remain high in pregnant women with polycystic ovary syndrome at term. Fertility and Sterility doi: 10.1016/j.fertnstert.2018.11.028. Piltonen TT, Giacobini P, Edvinsson A, Hustad S, Skalkidou A, Morin-Papunen L, Sundström-Poromaa I, Arffman RK (2019)

Preclinical Assessment of Leptin Transport into the Cerebrospinal Fluid in Diet-Induced Obese Minipigs. Obesity. 27:950-956. * Corresponding authors PMID: 31006983 * co-corresponding authors Chmielewski A, Hubert T, Descamps A, Mazur D, Daoudi M, Ciofi P, Fontaine C, Caiazzo R, Pattou F, Prevot V*, Pigeyre M*. (2019)

Emerging Roles of Anti-Müllerian Hormone in Hypothalamic-Pituitary Function. Barbotin AL, Peigné M, Malone SA, Giacobini P. Neuroendocrinology. 2019. 109,218-229.

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism. García-Cáceres C, Balland E, Prevot V, Luquet S, Woods SC, Koch M, Horvath TL, Yi CX, Chowen JA, Verkhratsky A, Araque A, Bechmann I, Tschöp MH. Nat Neurosci. 2019. 22,7-14.

Emerging Roles of Anti-Müllerian Hormone in Hypothalamic-Pituitary Function. Barbotin AL, Peigné M, Malone SA, Giacobini P Neuroendocrinology. 2019. doi: 10.1159/000500689.

Don’t Trust Your Gut: When Gut Microbiota Disrupt Fertility. Silva MSB, Giacobini P. Cell Metab. 2019, 30:616-618. doi: 10.1016/j.cmet.2019.09.005.

New Developments in Reproductive and Stress Neuroendocrinology. Prevot V, Millar RP. Neuroendocrinology. 2019, 109:191-192. doi: 10.1159/000502420.

Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis. Croizier, S., Park, S., Maillard, J. & Bouret, S.G. Elife 2018. 7: e40429

Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood Tata B, Mimouni NEH, Barbotin AL, Malone SA, Loyens A, Pigny P, Dewailly D, Catteau-Jonard S, Sundström-Poromaa I, Piltonen TT, Dal Bello F, Medana C, Prevot V, Clasadonte J, Giacobini P. Nat Med. 2018. doi: 10.1038/s41591-018-0035-5.

A comparative study of the neural stem cell niche in the adult hypothalamus of human, mouse, rat and grey mouse lemur (Microcebus murinus) Pellegrino G, Trubert C, Terrien J, Pifferi F, Leroy D, Loyens A, Migaud M, Baronicini M, Maurage CA, Fontaine C, Prevot V, Sharif A J Comp Neurol. 2018. 526(9):1419-1443

Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood Tata BK, Mimouni NEH, Barbotin AL, Malone SA, Loyens A, Pigny P, Dewailly D, Catteau-Jonard S, Sundström-Poromaa I, Piltonen TT, Dal Bello F, Medana C, Prevot V, Classadonte J, Giacobini P Nature Medicine. 2018. doi:10.1038/s41591-018-0035-5

A comparative study of the neural stem cell niche in the adult hypothalamus of human, mouse, rat and grey mouse lemur (Microcebus murinus) Pellegrino G, Trubert C, Terrien J, Pifferi F, Leroy D, Loyens A, Migaud M, Baronicini M, Maurage CA, Fontaine C, Prevot V, Sharif A J Comp Neurol. 2018. doi: 10.1002/cne.24376

Wired for eating: how is an active feeding circuitry established in the postnatal brain Muscatelli F, Bouret SG. Curr Opin Neurobiol. 2018. 52, 165-171.

Sex and gender differences in developmental programming of metabolism. Dearden L, Bouret SG, Ozanne SE. Mol Metab. 2018.15, 8-19.

The special relationship: glia-neuron interactions in the neuroendocrine hypothalamus Clasadonte J & Prevot V Nature Reviews Endocrinology. 2018, 14:25-44.

The versatile tanycyte: a hypothalamic integrator of reproduction and energy metabolism Prevot, V., B. Dehouck, A. Sharif, P. Ciofi, P. Giacobini, and J. Clasadonte. Endocrine Reviews. 2018. doi: 10.1210/er.2017-00235.

The versatile tanycyte: a hypothalamic integrator of reproduction and energy metabolism Prevot V, Dehouck B, Sharif A, Ciofi P, Giacobini P, Clasadonte J Endocrine Reviews. 2018. 1;39(3):333-368. doi: 10.1210/er.2017-00235

The special relationship: glia-neuron interactions in the neuroendocrine hypothalamus Clasadonte J & Prevot V Nature Reviews Endocrinology. 2018, doi:10.1038/nrendo.2017.124

Unveiling the Importance of Glia and Vascular Endothelial Cells in the Control of GnRH Neuronal Function Prevot V & Sharif A Herbison AE & Plant TM. The GnRH neuron and its Control. Wiley. Chapter 10, pp 225. doi 10.1002/9781119233275.ch10

Rôle des réseaux astrocytaires métaboliques dans le maintien de l’éveil Clasadonte J Med Sci (Paris) 2017; 34(3):199-202

Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle Clasadonte, J., E. Scemes, Z. Wang, D. Boison, and P.G. Haydon. Neuron. 2017. 95:1365-1380.e5.

Phenotyping of nNOS Neurons in the Postnatal and Adult Female Mouse Hypothalamus Chachlaki K, Malone SA, Qualls-Creekmore, Hrabovszky E, Munzberg H, Giacobini P, Ango F, Prevot V J Comp Neurol, 2017. 525:3177-3189

Tridimensional Visualization and Analysis of Early Human Development Belle M, Godefroy D, Couly G, Malone SA, Collier F, Giacobini P, Chedotal A Cell. 2017. 169:161-173 e112

Phenotyping of nNOS Neurons in the Postnatal and Adult Female Mouse Hypothalamus Chachlaki K, Malone SA, Qualls-Creekmore, Hrabovszky E, Munzberg H, Giacobini P, Ango F, Prevot V J Comp Neurol. 2017. 10.1002/cne.24257

Tridimensional Visualization and Analysis of Early Human Development Belle M, Godefroy D, Couly G, Malone SA, Collier F, Giacobini P, Chedotal A Cell. 2017 DOI: http://dx.doi.org/10.1016/j.cell.2017.03.008

Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis. Nature Communications doi: 10.1038/s41467-017-01429-z. Tommiska J, Känsäkoski J, Skibsbye L, Vaaralahti K, Liu X, Lodge EJ, Tang C, Yuan L, Fagerholm R, Kanters JK, Lahermo P, Kaunisto M, Keski-Filppula R, Vuoristo S, Pulli K, Ebeling T, Valanne L, Sankila E, Kivirikko S, Lääperi M, Casoni F, Giacobini P, et al., Raivio T (2017)

The gentle art of saying NO: how nitric oxide gets things done in the hypothalamus Chachlaki K, Garthwaite J, Prevot V Nature Reviews Endocrinology. 2017, doi:10.1038/nrendo.2017.69

Connecting metabolism and gonadal function: Novel central neuropeptide pathways involved in the metabolic control of puberty and fertility Manfredi-Lozano M, Roa J, Tena-Sempere M Frontiers in Neuroendocrinology. 2017, doi: 10.1016/j.yfrne.2017.07.008

When size matters: how astrocytic processes shape metabolism Cell Metab. 2017;25(5):995-996. Sharif A, Prevot V.

Hypothalamic microRNAs flip the switch for fertility. Oncotarget 8 : 8993-8994. Editorial. PMID: 28099896 Messina A, Prevot V (2017)

Les micro-ARN Nouveaux acteurs du contrôle hypothalamique de la fertilité Messina A, Langlet F, Prevot V Med Sci (Paris) 2017; 33:506-511

Tanycytes hypothalamiques, barrière hématoencéphalique et rôle dans la régulation de l’homéostasie énergétique Florent V, Baroncini M, Prevot V Cahiers de Nutrition et de Diététique, 52)1):26-32

Développement des neurones à GnRH dans le cerveau d’embryons humains Barbotin AL, Prevot V, Giacobini P Medi Sci (Pari) 2017; 33:376-379

Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains Casoni F, Malone SA, Belle M, Luzzati F, Collier F, Allet C, Hrabovszky E, Rasika S, Prevot V, Chédotal V, Giacobini P Development. 2016 143: 3969-3981; doi: 10.1242/dev.139444

Leptin controls parasympathetic wiring of the pancreas during embryonic lif Croizier S, Prevot V, Bouret SG Cell Reports. 2016 15, 36-44

Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits Maillard J, Park S, Croizier S, Vanacker C, Cook JH, Prevot V, Tauber M, and Bouret Hum Mol Genet. 25:3208-3215, 2016

A microRNA switch regulates the rise in hypothalamic GnRH production before puberty Messina A, Langlet F, Chachlaki K, Roa J, Rasika S, Jouy N, Gallet S, Gaytan F, Parkash J, Tena-Sempere M, Giacobini P, Prevot V Nat Neurosci. 2016 19, 835-844 doi:10.1038/nn.4298

Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion Cimino I, Casoni F, Liu X, Messina A, Parkash J, Soazik P, Catteau-Jonard S, Collier F, Baroncini M, Dewailly D, Pigny P, Prescott M, Campbell R, Herbison A, Prevot V, Giacobini P Nat Commun. 2016, 7:10055

Hypothalamic microRNAs flip the switch for fertility Messina A, Prevot V Oncotarget. 2016, DOI: 10.18632/oncotarget.14646

Reproduction: A kiss to set the rhythm Shruti S, Prevot V eLife. 5: pii: e19823. Commentary. PMID: 27558594

Programming the Brain from the Womb: Maternal Obesity Perturbs the Hypothalamic Blood-Brain Barrier Duquenne, M., Dehouck, B. & Prevot, V Endocrinology, 157:2201-2203, 2016

Coexpression profiles reveal hidden gene networks Chachlaki & Prevot PNAS (doi: 10.1073/pnas.1600717113)

Ontogeny of Neuroendocrine Feeding Circuits Croizier S & Bouret SG Dickson SL, Mercer JG (eds) Neuroendocrinology of Appetite. Wiley & Sons Ltd, c3

Control of fertility: New player identified Anti-Mullerian hormone: an ovarian hormone exerting hypothalamic feedback? Catteau-Jonard S, Dewailly D, Prevot V, Cimino I & Giacobini P Med Sci (Paris), 32:441-444, 2016 Maternal obesity alters social brain programming by altering gut microbiota in progeny Barbotin AL, Giacobini P, Prévot V Med Sci (Paris). 32930-932, 2016

Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP, Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.

Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin Collden G, Balland E, Parkash J, Caron E, Langlet F, Prevot V, and Bouret SG. Mol Metab. 2015, 4(1):15-24.

Neonatal ghrelin programs development of hypothalamic feeding circuits Steculorum SM, Collden G, Coupe B, Croizier S, Lockie S, Andrews ZB, Jarosch F, Klussmann S, and Bouret SG. J Clin Invest. 2015, 125(2):846-58.

European Consensus Statement on congenital hypogonadotropic hypogonadism—pathogenesis, diagnosis and treatment Boehm U., Bouloux P.M., Dattani M.T., de Roux N., Dodé C., Dunkel L., Dwyer A.A., Giacobini P., Hardelin JP., Juul A., Maghnie M., Pitteloud N., Prevot V., Raivio T., Tena-Sempere M., Quinton R. and Young J. (2015). Nature Reviews Endocrinology Endocrinology doi:10.1038/nrendo.2015.112.

Shaping the Reproductive System: Role of Semaphorins in Gonadotropin-Releasing Hormone Development and Function Giacobini, P Neuroendocrinology 102, 200-215, 2015

Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity Bouret, S., Levin, B.E. & Ozanne, S.E Physiol Rev 95, 47-82, 2015

Puberty in mice and rats Prevot V Plant, T.M., Zeleznik, J. (eds) Knobil and Neill’s Physiology of Reproduction. Elsevier, New York, pp 1395-1439, 2015

Endothelial cell plasticity in the normal and injured central nervous system Vanacker C, Sharif A, Prevot P Chapter 4, CRC Press, 2015

Dynamic Control of Neural Reproductive Centers by Endothelial cells. In: Endothelial Cell Plasticity in the Normal and Injured Central Nervous System (Herrera EM, Phillips-Farfán BV, Ospina GG, eds). CRC Press, January 1, 2015.  Vanacker C, Sharif A, Prevot V.

Leptin dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction Bellefontaine N, Chachlaki K, Parkash J, Vanaker C, Colledge W, d’Anglemont de Tassigny X, Garthwaite J, Bouret SG, Prevot V. J Clin Invest 124:2550-2559, 2014.

Brain Endothelial Cells Control Fertility through Ovarian- Steroid–Dependent Release of Semaphorin 3A. PLoS Biology doi: 10.1371/journal.pbio.1001808. Giacobini P., Parkash J., Campagne C., Messina A., Casoni F., Vanacker C., Langlet F., Hobo B., Cagnoni G., Gallet S., Hanchate N.K., Mazur D., Taniguchi M., Mazzone M., Verhaagen J., Ciofi P., Bouret S.G., Tamagnone L., Prevot V. (2014).

Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Cell Metab 19, 293-301. PMID: 24506870 Balland E, Dam J, Langlet F, Caron E, Steculorum S, Messina A, Rasika S, Falluel-Morel A, Anouar Y, Dehouck B, Trinquet E, Jockers R, Bouret SG, Prevot V (2014)

Leptin facilitates reproduction through neuronal nitric oxide signaling in the hypothalamic preoptic region. J Clin Invest 124:2550-2559. PMID: 24812663 Bellefontaine N, Chachlaki K, Parkash J, Vanaker C, Colledge W, d’Anglemont de Tassigny X, Garthwaite J, Bouret SG, Prevot V (2014)

Tanycytes: a gateway to the metabolic hypothalamus Langlet, F J Neuroendocrinol 26, 753-760, 2014

Neurogenesis and gliogenesis in the postnatal hypothalamus: a new level of plasticity for the regulation of hypothalamic function Sharif A, Ojeda SR, Prevot V Junier MP, Kernie SG eds. Endogenous Stem Cell-Based Brain Remodeling in Mammals, Stem Cell Biology and Regenerative Medicine. New York: Springer Science+Business Media, Chapter 6, pp 105-136, 2014

Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain Langlet F, Muller A, Bouret SG, Prevot V, Dehouck B. J Comp Neurol. 2013521(15):3389-405 doi: 10.1002/cne.23355

Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting. Cell Metab 17:607-617, 2013. (also Cell Metab Previews p. 467-468) * Corresponding author PMID: 23562080 Langlet F, Levin BE, Luquet S, Mazzone M, Messina A, Dunn-Meynell AA, Balland E, Lacombe A, Mazur D, Carmeliet P, Bouret SG, Prevot V*, Dehouck B.

Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons. Proc Natl Acad Sci U S A 110:1512-1517. PMID: 23297228 * Co-first authors. Schaeffer M*, Langlet F*, Lafont C, Molino F, Hodson DJ, Roux T, Lamarque L, Verdie P, Bourrier E, Dehouck B, Baneres JL, Martinez J, Mery PF, Marie J, Trinquet E, Fehrentz JA, Prevot V, Mollard P (2013)

The hypothalamic peptide melanin-concentrating hormone regulates ependymal cilia beat frequency and ventricle volume. Nat Neurosci 16:845-847. * Senior authors PMID: 23708141 Conductier G, Brau F, Viola A, Ramkumar N, Martin AO, Langlet F, Dehouck B, Lemaire T, Chapot R, Lucas L, Maitre P, Hosseiny S, Petit-Paitel A, Risold PY, Rovère C, Prévot V*, Meste O*, Nahon JL*, Guyon A* (2013)

Semaphorin signaling in the development and function of the gonadotropin hormone-releasing hormone system Messina A and Giacobini P Front. Endocrinol., 23 September 2013. doi: 10.3389/fendo.2013.00133, 2013

Flipping the tanycyte switch: how circulating signals gain direct access to the metabolic brain Prevot V, Langlet F, Dehouck B Aging 5:332-334, 2013

Semaphorins in the development, homeostasis and disease of hormone systems Giacobini P, Prevot V Semin Cell Dev Biol 24:190-198, 2013

Role of glia in the regulation of gonadotropin-releasing hormone neuronal activity and secretion Sharif A, Baroncini M, Prevot V Neuroendocrinology 98:1-15, 2013

Organizational actions of metabolic hormones Bouret, S.G Front Neuroendocrinol 34, 18-26, 2013

Role of glia in the regulation of gonadotropin-releasing hormone neuronal activity and secretion. Neuroendocrinology 2013 98(1):1-15. Sharif A, Baroncini M and Prevot V.

Semaphorin Signaling in the Development and Function of the Gonadotropin Hormone-Releasing Hormone (GnRH) System. Frontiers in Endocrinology 4:133.  Messina A. and Giacobini P.  (2013).

Suppression of β1-integrin in gonadotropin-releasing hormone cells disrupts migration and axonal extension resulting in severe reproductive alterations. Parkash J, Cimino I, Ferraris N, Casoni F, Wray S, Cappy H, Prevot V, Giacobini P. J Neurosci. 2012 Nov 21;32(47):16992-7002. doi: 10.1523/JNEUROSCI.3057-12.2012.

RIPping off GABA release in hypothalamic circuits causes obesity. Bouret SG. Cell Metab. 2012 Nov 7;16(5):557-8. doi: 10.1016/j.cmet.2012.10.014.

SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome. Hanchate NK, Giacobini P, Lhuillier P, Parkash J, Espy C, Fouveaut C, Leroy C, Baron S, Campagne C, Vanacker C, Collier F, Cruaud C, Meyer V, García-Piñero A, Dewailly D, Cortet-Rudelli C, Gersak K, Metz C, Chabrier G, Pugeat M, Young J, Hardelin JP, Prevot V, Dodé C. PLoS Genet. 2012 Aug;8(8):e1002896. doi: 10.1371/journal.pgen.1002896.

Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function. Caron E, Ciofi P, Prevot V, Bouret SG. J Neurosci. 2012 Aug 15;32(33):11486-94. doi: 10.1523/JNEUROSCI.6074-11.2012.

Embryonic birthdate of hypothalamic leptin-activated neurons in mice. Ishii Y, Bouret SG. Endocrinology. 2012 Aug;153(8):3657-67. doi: 10.1210/en.2012-1328.

Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation. Coupé B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG. Cell Metab. 2012 Feb 8;15(2):247-55. doi: 10.1016/j.cmet.2011.12.016.

Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits. Bouret SG, Bates SH, Chen S, Myers MG Jr, Simerly RB. J Neurosci. 2012 Jan 25;32(4):1244-52. doi: 10.1523/JNEUROSCI.2277-11.2012.

Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation. Hanchate NK, Parkash J, Bellefontaine N, Mazur D, Colledge WH, d’Anglemont de Tassigny X, Prevot V. J Neurosci. 2012 Jan 18;32(3):932-45. doi: 10.1523/JNEUROSCI.4765-11.2012.

MRI atlas of the human hypothalamus. Baroncini M, Jissendi P, Balland E, Besson P, Pruvo JP, Francke JP, Dewailly D, Blond S, Prevot V. Neuroimage. 2012 Jan 2;59(1):168-80. doi: 10.1016/j.neuroimage.2011.07.013.

Neuroendocrine control of reproduction Clarke IJ, Campbell R, Smith JT, Prevot V, Wray S In: Handbook of Neuroendocrinology (Fink G, Pfaff DW, Levine JE, Eds), Academic Press, San Diego, CA, Chapter 9, pp 197-235, 2012

Isolation and culture of human astrocytes Sharif A, Prevot V Methods Mol Biol 814:137-151, 2012

Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility. Messina A, Ferraris N, Wray S, Cagnoni G, Donohue DE, Casoni F, Kramer PR, Derijck AA, Adolfs Y, Fasolo A, Pasterkamp RJ, Giacobini P. Hum Mol Genet. 2011 Dec 15;20(24):4759-74. doi: 10.1093/hmg/ddr403.

Prostaglandin E2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activation. Clasadonte J, Poulain P, Hanchate NK, Corfas G, Ojeda SR, Prevot V. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16104-9. doi: 10.1073/pnas.1107533108.

Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring. Steculorum SM, Bouret SG. Endocrinology. 2011 Nov;152(11):4171-9. doi: 10.1210/en.2011-1279.

Nitric oxide as key mediator of neuron-to-neuron and endothelia-to-glia communication involved in the neuroendocrine control of reproduction Bellefontaine N, Hanchate NK, Parkash J, Campagne C, de Seranno S, Clasadonte J, d’Anglemont de Tassigny X, Prevot V Neuroendocrinology 93:74-89, 2011

Gliotransmission by prostaglandin E2: a prerequisite for GnRH neuronal function Clasadonte J, Sharif A, Baroncini M, Prevot V Front Endocrinol 2:1-12, 2011

GnRH neurons directly listen to the peripher  Prevot V Endocrinology 152: 3589-3591, 2011

Phosphorylation of N-methyl-D-aspartic acid receptor-associated neuronal nitric oxide synthase depends on estrogens and modulates hypothalamic nitric oxide production during the ovarian cycle. Parkash J, d’Anglemont de Tassigny X, Bellefontaine N, Campagne C, Mazure D, Buée-Scherrer V, Prevot V. Endocrinology. 2010 Jun;151(6):2723-35. doi: 10.1210/en.2010-0007.

Role of estradiol in the dynamic control of tanycyte plasticity mediated by vascular endothelial cells in the median eminence. De Seranno S, d’Anglemont de Tassigny X, Estrella C, Loyens A, Kasparov S, Leroy D, Ojeda SR, Beauvillain JC, Prevot V. Endocrinology. 2010 Apr;151(4):1760-72. doi: 10.1210/en.2009-0870.

Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain. Mullier A, Bouret SG, Prevot V, Dehouck B. J Comp Neurol. 2010 Apr 1;518(7):943-62. doi: 10.1002/cne.22273.

Distribution of leptin-sensitive cells in the postnatal and adult mouse brain. Caron E, Sachot C, Prevot V, Bouret SG J Comp Neurol. 2010 Feb 15;518(4):459-76. doi: 10.1002/cne.22219.

Sex steroid hormones-related structural plasticity in the human hypothalamus. Baroncini M, Jissendi P, Catteau-Jonard S, Dewailly D, Pruvo JP, Francke JP, Prevot V. Neuroimage. 2010 Apr 1;50(2):428-33. doi: 10.1016/j.neuroimage.2009.11.074.

Plasticity of neuroendocrine systems Prevot V Eur J Neurosci 32:1987-1988, 2010

GnRH nerve terminals, tanycytes and neurohaemal junction remodeling in the adult median eminence: functional consequences for reproduction and dynamic role of vascular endothelial cells Prevot V, Bellefontaine N, Baroncini M, Sharif A, Hanchate NK, Parkash J, Campagne C, de Seranno S J Neuroendocrinol 22:639-649, 2010

Function-related structural plasticity of the GnRH system: a role for neuronal-glial-endothelial interactions Prevot V, Hanchate NK, Bellefontaine N, Sharif A, Parkash J, Estrella C, Allet C, de Seranno S, Campagne C, de Tassigny X, Baroncini M Front Neuroendocrinol 31:241-258, 2010

ErbB receptor signaling in astrocytes: a mediator of neuron-glia communication in the mature central nervous system Sharif A, Prevot V Neurochem Int 57:344-358, 2010